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Retatrutide is a triple agonist (GIP, GLP-1, and glucagon receptors) while Ozempic activates only GLP-1 receptors, resulting in significantly greater weight loss, 24.2% versus 14.9% at standard doses

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In a study at the University of Zurich with 23 patients with coronary artery disease, endothelial function was assessed by measuring the flow-mediated dilatation (FMD) of the brachial artery ( per day or placebo was supplemented in a RDP cross-over study for eight weeks

Patients with type 2 diabetes may have practical reasons to start with semaglutide, since it has longer-established FDA approval and dosing data for that indication